Loss of δ-GABAAreceptor-mediated tonic currents in the adult prelimbic cortex following adolescent alcohol exposure
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چکیده
منابع مشابه
Stereological study of the cerebral and cerebellar cortex following short time exposure to morphine in rats
Drug abuse has been claimed to cause the loss of neurons and reduction of volume in both the adult and developing brain. This study examined cortex volumes in cerebrum and cerebellum of male rats that were dependent on morphine using unbiased stereological counting methods and systematic random sampling technique. Our goal was to test whether short time exposure to morphine can affect the corte...
متن کاملStereological study of the cerebral and cerebellar cortex following short time exposure to morphine in rats
Drug abuse has been claimed to cause the loss of neurons and reduction of volume in both the adult and developing brain. This study examined cortex volumes in cerebrum and cerebellum of male rats that were dependent on morphine using unbiased stereological counting methods and systematic random sampling technique. Our goal was to test whether short time exposure to morphine can affect the corte...
متن کاملAdolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior
Adolescence is a developmental period when physical and cognitive abilities are optimized, when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal cortical functions mature to adult levels. Adolescents also have unique responses to alcohol compared with adults, being less sensitive to ethanol sedative-motor responses that most likely contribute to binge drinki...
متن کاملThe modulation of orexin A on HCN currents of pyramidal neurons in mouse prelimbic cortex.
The hyperpolarization-activated/cyclic nucleotide (HCN)-gated channels make important contributions to neural excitability. In prefrontal cortex, HCN channels are localized on the distal dendrites of layer V pyramidal neurons and decrease neural excitability when they are open. In the present study, using whole-cell voltage clamp recordings, the effect of an arousal peptide, orexin A, on HCN cu...
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Background: Ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. The mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. We aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex b...
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ژورنال
عنوان ژورنال: Addiction Biology
سال: 2016
ISSN: 1355-6215
DOI: 10.1111/adb.12353